Advanced Hemodynamic Monitoring Devices for Smarter Critical Care
Bio-Si™ develops cutting-edge, mini-invasive technologies for real-time cardiovascular assessment
ABOUT US
Bio-Si International Srl was founded in 2004 to develop algorithms and equipment for the analysis of biological signals, and more specifically for the hemodynamic monitoring of the cardiovascular system.
Bio-Si™ is the exclusive licensee of the patents relating to the evaluation of cardiac output beat-to-beat through the Pressure Recording Analytical Method – PRAM™, invented by Dr. S. Mario Romano.
Based on these patents and its own applied research, in 2003 it designed and marketed a first medical device called Most-Care® followed, in 2015, by its evolution called MOSTCARE®Up
Algorithms developed on those patents were incorporated into this technology, both for evaluating the heart-circulation coupling and the problems associated with blood pressure measurement. This also made it possible to conceive a specific parameter (Cardiac Cycle Efficiency – CCE) for evaluating energy expenditure during a cardiac cycle.
A dynamic filter was also designed to eliminate the resonance problems associated with blood pressure measurement.
The effectiveness of these technologies is demonstrated by more than a hundred scientific studies published in peer-reviewed journals.
And now Bio-Si is continuing to pursue projects in the hemodynamic and cardiovascular fields to move the boundaries of its knowledge even further forward.
PRAM™
The Pressure Recording Analytical Method (PRAM™) is the patented algorithm allowing the precise analysis of the hemodynamic functions beat-to-beat and without calibration.
MOSTCARE®Up
INNOVATIVE
RELIABLE
CONVENIENT
The only monitor providing, beat-to-beat and in real time, the most advanced information on the hemodynamic balance of the widest range of patients.
DYNAMIC FILTER
Filter Underdamping
The arterial pressure curve can be easily affected, at least for transient periods, by artefacts that can lead to wrong estimations and results. The main one is the underdamping: in specific conditions, there could be a resonance in the pressure waves generating abnormal peaks of the systolic pressure (and some decrease of the diastolic one). Those artefacts can happen in all kinds of monitoring systems and can lead to a wrong measurement of the pressures.
Dynamic Filter
To deal with the underdamping, Bio-Si Srl developed an automatic dynamic filter which detects the presence of resonant waves and filters the frequency causing the anomaly of the curve, returning a pressure wave not affected by the artefact. Considering that the resonance can be a transitory phenomenon, the automatic filter repeats the analysis over the time and intervenes only when necessary.
This makes the hemodynamic monitoring much more reliable every time the underdamping is present.